Yibo Wen
Computer Science PhD Student @ Northwestern
I am a 1st year Computer Science Ph.D. student at Northwestern University, advised by Han Liu. My current research focuses on AI-driven drug discovery, in collaboration with AbbVie. I completed my undergraduate studies also at Northwestern, with prior research experience in Computer Graphics at the USC Institute for Creative Technologies and Sony Research.
I'm interested in computational molecular and antibody design, structure-based drug discovery, and integrating scientific priors with data-driven reasoning in biology. Beyond resesarch, I'm passionate about tennis and digital design.
News
I will join the Chan Zuckerberg Biohub Chicago this summer as a research intern.
I presented our work on model alignment for structure-based drug design at AbbVie.
I started my Ph.D. journey in the Computer Science Department at Northwestern University.
I joined the Vision & Graphics Lab at the USC Institute for Creative Technologies as a research intern.
Publications
AlignAb: Pareto-Optimal Energy Alignment for Designing Nature-Like Antibodies
Yibo Wen, Chenwei Xu, Jerry Yao-Chieh Hu, Han Liu
In Submission
We propose a three-stage framework combining language model pre-training, diffusion-based optimization, and energy-aligned fine-tuning. By extending Direct Preference Optimization for multi-objective alignment and introducing an iterative learning paradigm, our method achieves state-of-the-art performance in generating stable, high-affinity, and structurally realistic antibody candidates.
Efficient Encoding of Graphics Primitives with Simplex-based Structures
Yibo Wen*, Yunfan Yang*
MMLS 2023
We explored the possibility of encoding graphics primitives with simplex based structures. Inspired by simplex noise and its traditional counterpart Perlin noise, we implemented a similar algorithm with custom CUDA kernels based on simplex noise generation for volumetric rendering.
Convoice AI
Convoice enables you to build and deploy custom voicebots with ease, automating both inbounding and outbounding calls.
Built an engineering team of 4 person from scratch, designed all branding and interfaces, collaborated with large call centers and health industry leaders to automate customer service and sales support.
Ctrl+F Platform
The mission of Ctrl+F Platform is to connect students with on-campus research opportunities. Together with 4 other USC students, we helped to connect students with 100+ research or teaching assistant opportunities on campus.
We won the first place in 2022 Viterbi ABC Innovation Prize and received $6000 prize money from Viterbi School of Engineering.
Website Design & Development
Personal Projects
Modeling & Rendering
Student Union @ Shanghai High School
Investment Brochure for Xujing District, Shanghai
If you need help with digital design or website development, feel free contact me!
Which one is better?